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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (We further tested FAK splicing variants in breast neuroendocrine carcinoma (BrNECs), and foundWe explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 250-257 doi: 10.1007/s11684-016-0454-y

Abstract:

Alternative splicing plays a fundamental role in the development and physiological function of theAlternative splicing along the tonotopic axis of the cochlea contributes to frequency tuning, particularlyConsequently, deficits in alternative splicing have been shown to cause hearing loss, as we can observeDespite the advances in this field, the regulation of alternative splicing in the inner ear remains elusiveFurther investigation is also needed to clarify the mechanism of hearing loss caused by alternative splicing

Keywords： alternative splicing     inner ear     hearing loss     hair cells    

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Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 330-343 doi: 10.1007/s11684-017-0557-0

Abstract: Alternative splicing is a tightly regulated process that contributes to cancer development.CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several

Keywords： long noncoding RNA     CRNDE     alternative splicing    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3IMechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive splicing

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 186-195 doi: 10.1007/s11705-015-1540-4

Abstract: Increased expression levels of the RNA splicing regulator Transformer2 (abbreviated Tra2 ) have beenThis cross-regulation involves splicing control of a special class of exons, called poison exons.Down-regulation of Tra2 reduces splicing inclusion of a poison exon in the mRNA encoding Tra2 , therebyThis buffers any splicing changes that might be caused by individual depletion of Tra2 alone.These data suggest Tra2 proteins and/or their splicing targets as possible cancer drug targets.

Keywords： RNA splicing     gene expression     breast cancer     DNA damage     CHK1    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The splicing effect of c.1210-3C>G was verified via minigene assay in vitro, indicating that wild-typemutation in our patient, in combination with T5 sequence in cis, affects the CFTR gene splicing

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Biofuel as an alternative to oil—current industry progress and sustainable development

Li Shizhong

Strategic Study of CAE 2011, Volume 13, Issue 2,   Pages 50-56

Abstract: For the purpose of a sustainable social-economic development, biofuel is the most viable alternative

Keywords： biofuel     alternative to oil     transport     development    

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Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering

Bing WANG, Qingbin CUI, Shuibo ZHANG

Frontiers of Engineering Management 2019, Volume 6, Issue 2,   Pages 239-248 doi: 10.1007/s42524-019-0018-3

Abstract: levels are increasingly motivating the private sector to participate in infrastructure development using alternative

Keywords： infrastructure development     contract design     contract reliability     guarantee provision     contract engineering    

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A naive optimization method for multi-line systems with alternative machines

Weichang KONG, Fei QIAO, Qidi WU

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 4,   Pages 377-392 doi: 10.1007/s11465-019-0544-z

Abstract: Consequently, optimization of multi-line systems with alternative machines requires a simple mechanismTo define a general multi-line system with alternative machines, this study introduces the capability

Keywords： multi-line systems     alternative machines     feedback control     closed-loop optimization    

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AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 284-294 doi: 10.15302/J-FASE-2021435

Abstract:

Bioenergy, currently the largest renewable energy source in the EU (64% of the total renewable energy consumption), has sparked great interest to meet the 32% renewable resources for the 2030 bioeconomy goal. The design of innovative cropping systems informed by bioeconomy imperatives requires the evaluate of the effects of introducing crops for bioenergy into conventional crop rotations. This study aimed to assess the impacts of changes in conventional cropping systems in mixed dairy cattle farms redesigned to introduce bioenergy crops either by increasing the biomass production through an increase of cover crops, while keeping main feed/food crops, or by substituting food crops with an increase of the crop rotation length. The assessment is based on the comparison between conventional and innovative systems oriented to feed and biogas production, with and without tillage, to evaluate their agri-environmental performances (biomass production, nitrogen fertilization autonomy, greenhouse gas emissions and biogas production). The result showed higher values in the biogas cropping system than in the conventional and feed ones for all indicators, biomass productivity (27% and 20% higher, respectively), nitrogen fertilization autonomy (26% and 73% higher, respectively), methanogenic potential (77% and 41% higher, respectively) and greenhouse gas emissions (15% and 3% higher, respectively). There were no negative impacts of no-till compared to the tillage practice, for all tested variables. The biogas cropping system showed a better potential in terms of agri-environmental performance, although its greenhouse gas emissions were higher. Consequently, it would be appropriate to undertake a multicriteria assessment integrating agri-environmental, economic and social performances.

Keywords： alternative cropping systems / bioeconomy / biogas / biomass production / fertilization autonomy / greenhouse    

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Alternative energy development strategies for China towards 2030

Linwei MA , Zheng LI , Feng FU , Weidou NI , Xiliang ZHANG ,

Frontiers in Energy 2009, Volume 3, Issue 1,   Pages 2-10 doi: 10.1007/s11708-009-0014-0

Abstract: The purposes, objectives and technology pathways for alternative energy development are discussed withSpecial attention has been paid to alternative power and alternative vehicle fuels.Instead of limiting alternative energy to energy sources such as nuclear and renewable energy, the scopeof discussion is extended to alternative technologies such as coal power with carbon capture and sequestrationDesirable alternative fuels (or technologies) like 2nd generation biofuels and electrical vehicles should

Keywords： alternative energy     China energy     technology pathway     six-dimensional evaluation    

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Experimental study of pollution effect on the behavior of high voltage insulators under alternative current

Hani BENGUESMIA, Nassima M’ZIOU, Ahmed BOUBAKEUR

Frontiers in Energy 2021, Volume 15, Issue 1,   Pages 213-221 doi: 10.1007/s11708-017-0479-1

Abstract: In this paper, the impact of the conductivity and the distribution of pollution on the behavior of the high voltage insulator cap and pin 1512L, artificially polluted is described. An experimental model in form of a disc is proposed. This experimental model reproduces the real model which is the 1512L insulator. Besides, a comparative study is presented. For this comparative study, different solutions are adopted to s`imulate the pollution (containing NaCl+ distilled water) that has different conductivities for a discontinuous distribution of the pollution on the insulator under an AC voltage. Furthermore, the influence of the pollution on the flashover voltage and the leakage current is studied. Finally, the behavior of real and experimental model of the insulator is investigated.

Keywords： 1512L insulator     circular model     artificial pollution     flashover     leakage current     discontinuous pollution     high voltage    

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Dimethyl ether as alternative fuel for CI engine and vehicle

Zhen HUANG , Xinqi QIAO , Wugao ZHANG , Junhua WU , Junjun ZHANG ,

Frontiers in Energy 2009, Volume 3, Issue 1,   Pages 99-108 doi: 10.1007/s11708-009-0013-1

Abstract: It is of great importance to develop clean and alternative fuels for internal combustion engines.

Keywords： dimethyl ether (DME)     fuel injection     combustion process     emission control     CI engine     vehicle    

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Life cycle analysis and choice of natural gas-based automotive alternative fuels in Chongqing Municipality

WU Rui, LI Guangyi, ZHANG Zongyi, REN Yulong, HAN Weijian

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 292-298 doi: 10.1007/s11783-007-0049-6

Abstract: A reduction of emissions can be achieved by implementing alternative fuel chains.

Keywords： dedicated     primary     economic     alternative     abundant    

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Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation

Sergio A. MARTÍNEZ-GALVÁN, Miguel P. ROMO

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 1,   Pages 67-80 doi: 10.1007/s11709-017-0399-5

Abstract: This type of foundation seems to be a highly competitive alternative to the friction pile-box foundations

Keywords： deep foundations     bearing capacity     resistant moment     structural cell     3D numerical modeling    

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Title Author Date Type Operation

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Journal Article

Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers

Xuefei Ma, Wei Zhang, Rong Zhang, Jingming Li, Shufen Li, Yunlin Ma, Wen Jin, Kankan Wang

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive splicing

Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Biofuel as an alternative to oil—current industry progress and sustainable development

Li Shizhong

Journal Article

Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering

Bing WANG, Qingbin CUI, Shuibo ZHANG

Journal Article

A naive optimization method for multi-line systems with alternative machines

Weichang KONG, Fei QIAO, Qidi WU

Journal Article

AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS

Journal Article

Alternative energy development strategies for China towards 2030

Linwei MA , Zheng LI , Feng FU , Weidou NI , Xiliang ZHANG ,

Journal Article

Experimental study of pollution effect on the behavior of high voltage insulators under alternative current

Hani BENGUESMIA, Nassima M’ZIOU, Ahmed BOUBAKEUR

Journal Article

Dimethyl ether as alternative fuel for CI engine and vehicle

Zhen HUANG , Xinqi QIAO , Wugao ZHANG , Junhua WU , Junjun ZHANG ,

Journal Article

Life cycle analysis and choice of natural gas-based automotive alternative fuels in Chongqing Municipality

WU Rui, LI Guangyi, ZHANG Zongyi, REN Yulong, HAN Weijian

Journal Article

Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation

Sergio A. MARTÍNEZ-GALVÁN, Miguel P. ROMO

Journal Article